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A novel in vitro model for preclinical testing of the hemocompatibility of intravascular stents according to ISO 10993-4 by Stefan Sinn; Torsten Scheuermann; Stephan Deichelbohrer; Gerhard Ziemer; Hans P. Wendel is a Engineering article available to read on EtoBox.

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Subacute stent thrombosis, caused by undesired interactions between blood and the stent surface, is a major concern in the first few weeks following coronary artery stent implantation. The aim of this study was to establish a novel in vitro model for hemocompatibility testing of coronary artery stents according to ISO 10993-4. The model consists of a modified Chandler-Loop design with closed heparin-coated PVC Loops and a thermostated water bath. The tests were performed with anticoagulated human whole blood. After incubation in the loop, blood was analyzed for coagulation and inflammatory activation markers (TAT, b-TG, sP-selectin, SC5b-9 and PMN-elastase). Three different stent types with varying thrombogenicity were tested; statistically significant differences were found between the three stent types in measures of coagulation and platelet activation. The new Chandler-Loop model can be used as an alternative to animal and current in vitro models, especially for the determination of early events after stent implantation.

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Author

Stefan Sinn; Torsten Scheuermann; Stephan Deichelbohrer; Gerhard Ziemer; Hans P. Wendel

Publisher

Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0957-4530)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)