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Hybrid Liposome–erythrocyte Drug Delivery System for Tumor Therapy with Enhanced Targeting and Blood Circulation by Kehui Zhu; Yingcan Xu; Rui Zhong; Wanjing Li; Hong Wang; Yee Shan Wong; Subramanian Venkatraman; Jiaxin Liu; Ye Cao is a Engineering article available to read on EtoBox.

What is Hybrid Liposome–erythrocyte Drug Delivery System for Tumor Therapy with Enhanced Targeting and Blood Circulation about?

## Abstract Liposome, a widely used drug delivery system (DDS), still shows several disadvantages such as dominant clearance by liver and poor target organ deposition. To overcome the drawbacks of liposomes, we developed a novel red blood cell (RBC)–liposome combined DDS to modulate the tumor accumulation and extend the blood circulation life of the existing liposomal DDS. Here, RBCs, an ideal natural carrier DDS, were utilized to carry liposomes and avoid them undergo the fast clearance in the blood. In this study, liposomes could either absorbed onto RBCs’ surface or fuse with RBCs’ membrane by merely altering the interaction time at 37°C, while the interaction between liposome and RBCs would not affect RBCs’ characteristics. In the __in vivo__ antitumor therapeutic efficacy study, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes attached onto RBCs’ surfaces exhibited lung targeting effect (via RBC-hitchhiking approach) and reduced clearance in the liver, while DPPC liposomes fused with RBCs had prolong blood circulation up to 48 h and no enrichment in any organ. Furthermore, 20 mol% of DPPC liposomes were replaced with pH-sensitive phospholipid 1,2-dioleoyl-Sn-glycer

Who reads Hybrid Liposome–erythrocyte Drug Delivery System for Tumor Therapy with Enhanced Targeting and Blood Circulation?

Author

Kehui Zhu; Yingcan Xu; Rui Zhong; Wanjing Li; Hong Wang; Yee Shan Wong; Subramanian Venkatraman; Jiaxin Liu; Ye Cao

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN

Field

Engineering (Physical Sciences)