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Interleukin-1β immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: Evidence for activity-dependent release by John A. Watt; Nicole K. Hobbs is a Neuroscience article available to read on EtoBox.
What is Interleukin-1β immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: Evidence for activity-dependent release about?
Interleukin-1beta has been demonstrated in neurons of the rat hypothalamus, including cells of the magnocellular neurosecretory system and tuberoinfundibular system (Lechan et al., [1990] Brain Res. 514:135-140). Despite its potential importance to regulation of neuroendocrine function, however, neither the specific cell types that express interleukin-1beta or the conditions that may result in its release have yet been described. Therefore, we utilized a combination of immunocytochemical and immunoelectron microscopic localization, in conjunction with Western blot analysis, on normonatremic, hypernatremic, and lactating rats to assess the site of synthesis and potential secretion characteristics of interleukin-1beta in the rat magnocellular neurosecretory system. Interleukin-1beta immunoreactivity was localized within both oxytocin and vasopressin neurons in the paraventricular, supraoptic, accessory and periventricular hypothalamic nuclei. Additionally, interleukin-1beta immunoreactive fibers were localized in the zona interna and zona externa of the median eminence and in the neurohypophysis. Immunoelectron microscopic analysis revealed that interleukin-1beta immunoreactivity is
Who reads Interleukin-1β immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: Evidence for activity-dependent release?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- John A. Watt; Nicole K. Hobbs
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2000
- Language
- EN
- Field
- Neuroscience (Life Sciences)