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(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial by Frank Bloos; Jürgen Held; Stefan Kluge; Philipp Simon; Klaus Kogelmann; Geraldine de Heer; Sven-Olaf Kuhn; Dominik Jarczak; Johann Motsch; Gunther Hempel; Norbert Weiler; Andreas Weyland; Matthias Drüner; Matthias Gründling; Patrick Meybohm; Daniel Richter; Ulrich Jaschinski; Onnen Moerer; Ulf Günther; Dirk Schädler; Raphael Weiss; Christian Putensen; Ixchel Castellanos; Oliver Kurzai; Peter Schlattmann; Oliver A. Cornely; Michael Bauer; Daniel Thomas-Rüddel; Ulrich Jaschinski; Christian Putensen; Matthias Drüner; Ixchel Castellanos; Stefanie Schmidt; Andreas Wehrfritz; Diana Kränzlein; Jürgen Held; Kai Zacharowski; Haitham Mutlak; Simone Lindau; Carolin Wiedenbeck; Onnen Mörer; Sven-Olaf Kuhn; Matthias Gründling; Stephan Kluge; Geraldine de Heer; Dominik Jarczak; Johann Motsch; Daniel Richter; Markus A. Weigand; Frank Bloos; Michael Bauer; Daniel Thomas-Rüddel; Peter Schlattmann; Thomas Lehmann; Norbert Weiler; Dirk Schädler; Oliver A. Cornely; Philipp Simon; Gunther Hempel; Raphael Weiss; Alexander Zarbock; Ulf Günther; Georg Rohe; Andreas Weyland; Oliver Kurzai; Grit Walter; Patrick Meybohm; Philipp Helmer; the SepNet Study Group is a Medicine article available to read on EtoBox.

What is (1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial about?

## Purpose To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive Candida infection (ICI). ## Methods Multicenter, randomized, controlled trial carried out between September 2016 and September 2019 in 18 intensive care units enrolling adult sepsis patients at high risk for ICI. Patients in the control group received targeted antifungal therapy driven by culture results. In addition to targeted therapy, patients in the BDG group received antifungals if at least one of two consecutive BDG samples taken during the first two study days was ≥ 80 pg/mL. Empirical antifungal therapy was discouraged in both groups. The primary endpoint was 28-day-mortality. ## Results 339 patients were enrolled. ICI was diagnosed in 48 patients (14.2%) within the first 96 h after enrollment. In the BDG-group, 48.8% (84/172) patients received antifungals during the first 96 h after enrollment and 6% (10/167) patients in the control group. Death until day 28 occurred in 58 of 172 patients (33.7%) in the BDG group and 51 of 167 patients (30.5%) in the control group (relative risk 1.10; 95% confide

Who reads (1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial?

Author

Frank Bloos; Jürgen Held; Stefan Kluge; Philipp Simon; Klaus Kogelmann; Geraldine de Heer; Sven-Olaf Kuhn; Dominik Jarczak; Johann Motsch; Gunther Hempel; Norbert Weiler; Andreas Weyland; Matthias Drüner; Matthias Gründling; Patrick Meybohm; Daniel Richter; Ulrich Jaschinski; Onnen Moerer; Ulf Günther; Dirk Schädler; Raphael Weiss; Christian Putensen; Ixchel Castellanos; Oliver Kurzai; Peter Schlattmann; Oliver A. Cornely; Michael Bauer; Daniel Thomas-Rüddel; Ulrich Jaschinski; Christian Putensen; Matthias Drüner; Ixchel Castellanos; Stefanie Schmidt; Andreas Wehrfritz; Diana Kränzlein; Jürgen Held; Kai Zacharowski; Haitham Mutlak; Simone Lindau; Carolin Wiedenbeck; Onnen Mörer; Sven-Olaf Kuhn; Matthias Gründling; Stephan Kluge; Geraldine de Heer; Dominik Jarczak; Johann Motsch; Daniel Richter; Markus A. Weigand; Frank Bloos; Michael Bauer; Daniel Thomas-Rüddel; Peter Schlattmann; Thomas Lehmann; Norbert Weiler; Dirk Schädler; Oliver A. Cornely; Philipp Simon; Gunther Hempel; Raphael Weiss; Alexander Zarbock; Ulf Günther; Georg Rohe; Andreas Weyland; Oliver Kurzai; Grit Walter; Patrick Meybohm; Philipp Helmer; the SepNet Study Group

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)