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Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study by Baiyong Shen; Yanyun Li; Chang-Sheng Sheng; Lili Liu; Tianzhichao Hou; Nan Xia; Siming Sun; Ya Miao; Yi Pang; Kai Gu; Xiongxiong Lu; Chenlei Wen; Yi Cheng; Yulin Yang; Dan Wang; Yijie Zhu; Minna Cheng; Katie Harris; Zachary T. Bloomgarden; Jingyan Tian; John Chalmers; Yan Shi is a Medicine article available to read on EtoBox.
What is Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study about?
## Summary ## Background The aim of the study is to estimate the incidence of pancreatic cancer among individuals with new-onset type 2 Diabetes (T2DM) and evaluate the relationship of pancreatic cancer risk with age at diabetes onset and diabetes duration. ## Methods This longitudinal cohort study included 428,362 new-onset T2DM patients in Shanghai and Mendelian randomization (MR) in the east-Asian population were used to investigate the association. Incidence rates of pancreatic cancer in all patients and by subgroups were calculated and compared to the general population. ## Findings A total of 1056 incident pancreatic cancer cases were identified during eight consecutive years of follow-up. The overall pancreatic cancer annual incidence rate was 55·28/100,000 person years in T2DM patients, higher than that in the general population, with a standardized incidence ratio (SIR) of 1·54 (95% confidence interval [CI], 1·45–1·64). The incidence of pancreatic cancer increased with age and a significantly higher incidence was observed in the older groups with T2DM. However, the relative pancreatic cancer risk was inversely related to age of T2DM onset, and a higher SIR of 5·73 (95%CI,
Who reads Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: Results from a longitudinal cohort and mendelian randomization study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Baiyong Shen; Yanyun Li; Chang-Sheng Sheng; Lili Liu; Tianzhichao Hou; Nan Xia; Siming Sun; Ya Miao; Yi Pang; Kai Gu; Xiongxiong Lu; Chenlei Wen; Yi Cheng; Yulin Yang; Dan Wang; Yijie Zhu; Minna Cheng; Katie Harris; Zachary T. Bloomgarden; Jingyan Tian; John Chalmers; Yan Shi
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)