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Computing Multiple Cell Kinetic Properties from a Single Time Point by R.A. White is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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New developments in experimental procedures have made it necessary to extend the theory for describing the movement of a population of cells and estimating the kinetic properties of the population. The new procedures are based on the use of fluorescent monoclonal antibodies to halogenated analogues of thymidine, which are incorporated as a label into cells during DNA synthesis. These populations may be examined by dual-parameter flow cytometry to discriminate between the labelled and unlabelled populations of cells and define their position within the DNA reproductive cycle. A particular need exists for a theory that can be used for measurements of tumors in which many cells are not actively cycling and only a single time point can be obtained. In order to develop a useful theory for evaluating the kinetic properties of the cells observed by these techniques, the standard methods of theoretical cell kinetics have been recast in z form that is amenable to the type of analysis demanded by these constraints and a novel method for the rapid analysis of the kinetic properties of the cell population is presented. The method is shown to yield a direct measurement for the population doubli

Who reads Computing Multiple Cell Kinetic Properties from a Single Time Point?

Author

R.A. White

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

1989

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)