Opening book details…
Can I read Serum Enterolactone and Postmenopausal Breast Cancer Risk by Estrogen, Progesterone and Herceptin 2 Receptor Status on EtoBox?
Serum Enterolactone and Postmenopausal Breast Cancer Risk by Estrogen, Progesterone and Herceptin 2 Receptor Status by Aida Karina Zaineddin; Alina Vrieling; Katharina Buck; Susen Becker; Jakob Linseisen; Dieter Flesch‐Janys; Rudolf Kaaks; Jenny Chang‐Claude is a Medicine article available to read on EtoBox.
What is Serum Enterolactone and Postmenopausal Breast Cancer Risk by Estrogen, Progesterone and Herceptin 2 Receptor Status about?
## Abstract Lignans are a group of estrogenic compounds present in plants. Several epidemiological studies proposed that lignans may protect against breast cancer by exerting anticarcinogenic activity. Levels of enterolactone were determined in serum samples of 1,250 cases and 2,164 controls from a large population‐based case–control study. We assessed the association between serum enterolactone and postmenopausal breast cancer risk using conditional logistic regression accounting for potential risk and confounding factors. Fractional polynomials were used to determine the function that best fitted the data. Moreover, we assessed heterogeneity by estrogen/progesterone/herceptin (ER/PR/HER2) status of the tumor. Additionally, a meta‐analysis with seven further studies addressing enterolactone concentrations and breast cancer risk was performed. Postmenopausal breast cancer risk decreased with increasing serum enterolactone levels [highest compared to lowest quintile: [odds ratio = 0.65; 95% confidence interval (CI) 0.52–0.83, __p__~trend~ = <0.0001]. A significant inverse association for ER+/PR+ as well as ER−/PR− tumors was observed, with a significantly stronger association for ER
Who reads Serum Enterolactone and Postmenopausal Breast Cancer Risk by Estrogen, Progesterone and Herceptin 2 Receptor Status?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Aida Karina Zaineddin; Alina Vrieling; Katharina Buck; Susen Becker; Jakob Linseisen; Dieter Flesch‐Janys; Rudolf Kaaks; Jenny Chang‐Claude
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)