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Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis by Tao Yang; Ruilin Wang; Honghong Liu; Lifu Wang; Jianyu Li; Shihua Wu; Xing Chen; Xiangdong Yang; Yanling Zhao is a Neuroscience article available to read on EtoBox.
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## Aims: We will investigate the anti-inflammatory activities of berberine (bbr) in treating chronic atrophic gastritis (cag) induced by helicobacter pylori (h. pylori). furthermore, the underlying molecular mechanisms of bbr also will be explored systematically. ## Materials and methods: Rats were infected by h. pylori. lipopolysaccharide (lps) and h. pylori were applied to induce m1 mφs polarization, interleukin 4 (il-4) and bbr were used to induce m2 mφs polarization. supernatants of polarized mφs were collected as conditioned media (cm) for investigating the impact of mφs and its' secreted cytokine on gastric epithelial cells (ges-1). cell viability, morphology, proliferation, and quantitative analysis of raw 264.7 cells and ges-1 cells were detected by high-content screening (hcs) imaging assay. to further investigate the potential mechanisms of bbr, relative mrna, immunohistochemistry and protein expression were measured. ## Key findings: Bbr inhibited m1-polarized mφs, which was induced by h. pylori and lps, and advocated m2-polarized mφs. the m1-specific markers (tnf-α and ifn-γ) in supernatants were reduced significantly and m2 specific markers (tgf-β and il-10) were incre
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- Author
- Tao Yang; Ruilin Wang; Honghong Liu; Lifu Wang; Jianyu Li; Shihua Wu; Xing Chen; Xiangdong Yang; Yanling Zhao
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0024-3205)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)