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NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice by Shin Maeda; Yohko Hikiba; Hiroaki Fujiwara; Tsuneo Ikenoue; Soichiro Sue; Makoto Sugimori; Mao Matsubayashi; Hiroaki Kaneko; Kuniyasu Irie; Tomohiko Sasaki; Makoto Chuma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice about?
## Abstract Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition, affecting up to 25% of the population worldwide. NAFLD has been linked to several conditions, including hepatic inflammation, fibrosis, and hepatocellular carcinoma (HCC), however the role of NAFLD in cholangitis and the development of cholangiocellular carcinoma (CCC) remains poorly understood. This study investigated whether a high‐fat diet (HFD) promotes cholangitis and the development of CCC in mice. We used liver‐specific E‐cadherin gene (__CDH1__) knockout mice, __CDH1^∆Liv^__, which develop spontaneous inflammation in the portal areas along with periductal onion skin‐like fibrosis, similar to that of primary sclerosing cholangitis (PSC). An HFD or normal diet (ND) was fed to __CDH1^∆Liv^__ mice for 7 mo. In addition, __CDH1^∆Liv^__ mice were crossed with __LSL‐Kras^G12D^__ mice, fed an HFD, and assessed in terms of liver tumor development. The extent of cholangitis and number of bile ductules significantly increased in mice fed an HFD compared with ND‐administered __CDH1^∆Liv^__ mice. The numbers of Sox9 and CD44‐positive stem cell‐like cells were significantly increased in HFD mice. __
Who reads NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shin Maeda; Yohko Hikiba; Hiroaki Fujiwara; Tsuneo Ikenoue; Soichiro Sue; Makoto Sugimori; Mao Matsubayashi; Hiroaki Kaneko; Kuniyasu Irie; Tomohiko Sasaki; Makoto Chuma
- Publisher
- John Wiley and Sons Inc.
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)