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Redox Chemistry of 8‐Azaadenine: a Pulse Radiolysis Study by G. Pramod; H. Mohan; P. Manoj; T. K. Manojkumar; V. M. Manoj; J. P. Mittal; C. T. Aravindakumar is a Chemistry article available to read on EtoBox.

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## Abstract Aza derivatives of purines and pyrimidines are important class of compounds, which are known for their cytotoxic, antimicrobial, and mutagenic activities. The redox chemistry of 8‐azaadenine (8AA) has been investigated using pulse radiolysis technique. The oxidation reactions were studied using hydroxyl radical (^**.**^OH), oxide radical anion (O^**.**−^ and sulfate radical anion (SO), and the reduction reactions were studied using hydrated electron (e) and hydrogen radical (H^**.**^). In the reaction of ^**.**^OH, a bimolecular rate constant of 3.8 × 10^8^ dm^3^ mol^−1^ s^−1^ was determined at pH 6.0. The transient spectrum obtained for the reaction of ^**.**^OH at pH 6 has an absorption maximum around 340 nm and is assigned to the formation of 8AA‐4OH^**.**^. The charge population density was calculated theoretically (using Gaussian 98) and it showed that the fourth carbon atom (C(4)) is the most probable site for the attack of ^**.**^OH. The oxidizing nature of this radical is demonstrated by its reaction with __N__,__N__,__N__′,__N__′‐tetramethyl‐__p__‐phenylenediamine (TMPD). The existence of this species is further supported by theoretical calculations where the a

Who reads Redox Chemistry of 8‐Azaadenine: a Pulse Radiolysis Study?

Author

G. Pramod; H. Mohan; P. Manoj; T. K. Manojkumar; V. M. Manoj; J. P. Mittal; C. T. Aravindakumar

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0894-3230)

Published

2006

Language

EN

Field

Chemistry (Physical Sciences)