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Liraglutide Augments Weight Loss After Laparoscopic Sleeve Gastrectomy: a Randomised, Double-Blind, Placebo-Control Study by Uttam Thakur; Anil Bhansali; Rajesh Gupta; Ashu Rastogi is a Medicine article available to read on EtoBox.

What is Liraglutide Augments Weight Loss After Laparoscopic Sleeve Gastrectomy: a Randomised, Double-Blind, Placebo-Control Study about?

## Purpose: Both laparoscopic sleeve gastrectomy (lsg) and liraglutide cause a significant weight loss. we evaluated the effect of liraglutide in comparison with placebo on total weight loss (twl) and excess body weight loss (ewl) and when added in initial weight loss period after lsg in obese individuals. ## Material and methods: Participants with bmi > 30 kg/m undergoing lsg were randomised to receive either liraglutide (subcutaneous) in increasing does of 0.6 mg/day until maximum tolerated dose of 3.0 mg (l-l group) or placebo (l-p group) from 6 weeks post-operative until 6 months. weight, bmi, %twl, %ewl, hba1c, fasting plasma glucose, homa-ir, resolution of type 2 diabetes mellitus, hypertension, dyslipidaemia, sleep apnea and quality of life were evaluated. primary end point was %twl and % ewl at post-operative 6 months. ## Results: Thirty participants underwent lsg, and 23 were randomised to receive liraglutide (n = 12) or placebo (n = 11).the mean dose of liraglutide in l-l group was 1.41 ± 0.49 mg/day. patients in l-l group had %twl of 28.2 ± 5.7 and %ewl of 58.7 ± 14.3 as compared with 23.2 ± 6.2 (p = 0.116) and 44.5 ± 8.6 (p = 0.043) in l-p group at 24 weeks, respectivel

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Author

Uttam Thakur; Anil Bhansali; Rajesh Gupta; Ashu Rastogi

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Medicine (Health Sciences)