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Telomere Length and Chromosomal Fragility Increase in Car Painters Exposed to Organic Solvents by Ana Milena Monsalve-Lancheros; Narda Cecilia González-Rincón; Milcíades Ibáñez-Pinilla; Sandra Ramírez-Clavijo is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Telomere Length and Chromosomal Fragility Increase in Car Painters Exposed to Organic Solvents about?
Objective To comparing the chromosome fragility ratio and relative telomere length, of a group of car painters occupationally exposure to organic solvents with a group of non-exposed individuals in the city of Bogotá (Colombia). Methods This was a retrospective study of two cohorts (33 men each), matched by age (±2 years) at 1:1 ratio. The differences in the fragility ratio and relative telomere length distributions were determined for both groups. Case group was composed for adult males working in artisanal shops located in Bogotá (Colombia), who were occupationally exposed to organic solvents through automotive painting for a minimum of two years. Blood samples were analyzed. The chromosomal fragile sites were detected using cytogenetics techniques and DNA was extracted to determine the length of telomeres using qPCR (Cawthon’s method). Chromosomal fragility ratio and relative telomeric length were compared between car painters exposed to organic solvents and no-exposed individuals. Results Statistically significant differences in Chromosomal fragility ratio were found between exposed (0.645 ± 0.440, med = 0.520) and non-exposed (0.414 ± 0.217, med = 0.400) (p = 0.037, Wilcoxon o
Who reads Telomere Length and Chromosomal Fragility Increase in Car Painters Exposed to Organic Solvents?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Ana Milena Monsalve-Lancheros; Narda Cecilia González-Rincón; Milcíades Ibáñez-Pinilla; Sandra Ramírez-Clavijo
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Agricultural and Biological Sciences (Physical Sciences)