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Chlordecone (Kepone®)-potentiated Carbon Tetrachloride Hepatotoxicity in Partially Hepatectomized Rats — a Histomorphometric Study by Prasada Rao S. Kodavanti; Urmila M. Joshi; Harihara M. Mehendale; Virginia G. Lockard is a Environmental Science article available to read on EtoBox.
What is Chlordecone (Kepone®)-potentiated Carbon Tetrachloride Hepatotoxicity in Partially Hepatectomized Rats — a Histomorphometric Study about?
Our previous studies indicated the involvement of some unidentified mechanisms, apart from the bioactivation phenomenon, in chlordecone (CDkpotentiated CCI, hepatotoxicity and lethality. Recent studies revealed that hepatocellular regeneration is suppressed in CD + CCI, toxicity. The present work is a continuation of our earlier work employing a partial hepatectomy model for stimulating hepatocellular division, in normal (N) or CD-treated (10 ppm for 15 days) rats. Male Sprague-Dawley rats maintained on an appropriate dietary protocol and undergoing sham (SH) or partial hepatectomies (PH) were employed. Hepatocellular regeneration was assessed by measuring the percentage mitotic figures and by autoradiography of liver sections from rats given "-thymidine in vivo. Hepatotoxicity was assessed by examining liver sections for necrotic cells, swollen cells and cells having lipid droplets. CCI, (100 kl kg ~ I )-induced histopathological alterations in CD-pretreated rats were significantly decreased in rats 2 days post-PH (PH2) as compared to SH rats or rats 7 days post-PH (PH,). indicating that amplification of CCl, toxicity is significantly reduced when there is a greater regenerative a
Who reads Chlordecone (Kepone®)-potentiated Carbon Tetrachloride Hepatotoxicity in Partially Hepatectomized Rats — a Histomorphometric Study?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Prasada Rao S. Kodavanti; Urmila M. Joshi; Harihara M. Mehendale; Virginia G. Lockard
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)
- Published
- 1989
- Language
- EN
- Field
- Environmental Science (Physical Sciences)