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SHMT2 Induces Stemness and Progression of Head and Neck Cancer by Yanli Jin; Seung-Nam Jung; Mi Ae Lim; Chan Oh; Yudan Piao; Hae Jong Kim; QuocKhanh Nguyena; Yea Eun Kang; Jae Won Chang; Ho-Ryun Won; Bon Seok Koo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Various enzymes in the one-carbon metabolic pathway are closely related to the development of tumors, and they can all be potential targets for cancer therapy. Serine hydroxymethyltransferase2 (SHMT2), a key metabolic enzyme, is very important for the proliferation and growth of cancer cells. However, the function and mechanism of SHMT2 in head and neck cancer (HNC) are not clear. An analysis of The Cancer Genome Atlas (TCGA) data showed that the expression of SHMT2 was higher in tumor tissue than in normal tissue, and its expression was significantly associated with male sex, aggressive histological grade, lymph node metastasis, distant metastasis, advanced TNM stage, and lymphovascular invasion in HNC. SHMT2 knockdown in FADU and SNU1041 cell lines significantly inhibited cell proliferation, colony formation, migration, and invasion. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using TCGA data revealed that SHMT2 was closely related to cancer stem cell regulation and maintenance. Furthermore, we found that silencing SHMT2 inhibited the expression of stemness markers and tumor spheroid formation compared with a con

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Author

Yanli Jin; Seung-Nam Jung; Mi Ae Lim; Chan Oh; Yudan Piao; Hae Jong Kim; QuocKhanh Nguyena; Yea Eun Kang; Jae Won Chang; Ho-Ryun Won; Bon Seok Koo

Publisher

MDPI AG

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)