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Can I read Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase on EtoBox?
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase by Huaqing Cui; Gian Filippo Ruda; Juana Carrero-Lérida; Luis M. Ruiz-Pérez; Ian H. Gilbert; Dolores González-Pacanowska is a Chemistry article available to read on EtoBox.
What is Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase about?
Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) has a central role in purine salvage and inhibitors of the enzyme have been shown to have antiplasmodial activity. The enzyme preferentially uses inosine as substrate (K m 1⁄4 5 mM, ). In an effort to identify new PfPNP inhibitors, two series of compounds were prepared. Series 1 was based on known human uridine phosphorylase inhibitors whilst series 2 was uracil equivalents of purine-based PNP transition state inhibitors. These two series of compounds were assayed for inhibition of both PfPNP activity and growth of P. falciparum. The transition state analogues were found to be moderate inhibitors of PfPNP (most potent compound, K i 1⁄4 6 mM).
Who reads Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Huaqing Cui; Gian Filippo Ruda; Juana Carrero-Lérida; Luis M. Ruiz-Pérez; Ian H. Gilbert; Dolores González-Pacanowska
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)