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In vivo dynamic MR imaging of MBP-induced acute experimental allergic encephalomyelitis in Lewis rat by I. J. Namaer; J. Steibel; P. Poulet; J. P. Armspach; Y. Mauss; J. Chambron is a Medicine article available to read on EtoBox.

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## Abstract A dynamic __in vivo__ study by MRI consisting of the measurement of relaxation times and in the visualization of the BBB permeability by Gd—DOTA was performed in an MBP‐induced acute EAE model of Lewis rat. Fourteen rats were immunized with an MBP/CFA mixture, eight by CFA alone, and three control rats were used to test the harmless effect of repeatedly performed MRI examinations. Beginning on the 8th or 9th days and in parallel with the emergence of clinical signs, rats immunized by the MBP/CFA mixture showed slight increases of relaxation times and of the BBB permeability. These abnormalities which always remain localized in the periventricular regions, become more pronounced toward the 10th and 11th days, just before (or at the same time) as paraplegia manifestations. After a plateau of a few days, they diminish with the clinical signs. This close correlation found __in vivo__ establishes the essential role of BBB in the pathogenesis of clinical signs of this EAE model. © 1992 Academic Press, Inc.

Who reads In vivo dynamic MR imaging of MBP-induced acute experimental allergic encephalomyelitis in Lewis rat?

Author

I. J. Namaer; J. Steibel; P. Poulet; J. P. Armspach; Y. Mauss; J. Chambron

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1992

Language

EN

Field

Medicine (Health Sciences)