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Groundnut ( Apios americana Medik) Extract Enhances the Osteoblast Differentiation of MC3T3-E1 Cells by Masanori Horie; Sakiko Sugino; Atsumi Tada; Kazuhiro Nara is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Groundnut ( Apios americana Medik) Extract Enhances the Osteoblast Differentiation of MC3T3-E1 Cells about?

The effects of groundnut (Apios americana Medik) extract on osteoblast differentiation were examined using MC3T3-E1 cells. MC3T3-E1 cells were treated with the crude extract along with other differentiating reagents. The alkaline phosphatase (ALP) activity of cells cultured in a differentiation medium supplemented with 0.01% crude groundnut extract was 1.5-1.6 times higher than that of cells cultured in a differentiation medium without the extract. Crude groundnut extract was further separated into aqueous and methanol fractions. The methanol fraction enhanced ALP activity, osteocalcin, integrin-binding sialoprotein, and type I collagen expression, and calcium mineralization. Conversely, the aqueous fraction did not show such effects. Groundnut extract may enhance osteoblast differentiation, and this effect is likely conferred by water insoluble substance(s).

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Author

Masanori Horie; Sakiko Sugino; Atsumi Tada; Kazuhiro Nara

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)