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What is CD4+ T Cell Exhaustion in Chronic HIV about?
Chronic human immunodeficiency virus (HIV) infection was characterized by progressive immune dysfunction, in which CD4+ T cell depletion and exhaustion play pivotal roles. CD4+ T cell exhaustion, marked by impaired proliferative capacity and sustained expression of inhibitory receptors, contributes to poor immune reconstitution despite effective antiretroviral therapy. Biomarkers such as programmed cell death protein 1 (PD-1), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), cyto
- Author
- publication1
- Language
- EN