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Association of MTHFR gene polymorphisms with glioma and meningioma patients in Indian population by R. Kumawat; S.H. Gowda; E. Debnath; S. Rashid; R. Niwas; A. Suri; C. Sarkar; S. Sinha; K. Chosdol is a Medicine article available to read on EtoBox.

What is Association of MTHFR gene polymorphisms with glioma and meningioma patients in Indian population about?

Background: The epidermal growth factor receptor (EGFR) and its truncated autoactive form, EGFRvIII, are amplified/overexpressed in 60% and 30% of gliomas, respectively, and are integral to gliomagenesis. Several antibodies have been developed to neutralise the activity of these two receptors; however, promising pre-clinical data has not translated to clinical success for unknown reasons, with cetuximab (phase II) and nimotuzumab (phase III) failing to improve patient outcomes. Methods: To investigate reasons for this, we analysed EGFRvIII-bearing primary neurosphere cell lines after antibody treatment using conventional and native western for EGFR/EGFRvIII status, proliferation assays, immunofluorescence assays and in vivo orthotopic tumour models. Results: We report that several clinical and pre-clinical antibodies (cetuximab, nimotuzumab, necitumumab and matuzumab) do not neutralise EGFRvIII auto-activity, leading to sustained cellular proliferation. The antibody ch806 neutralised EGFRvIII but not wtEGFR. Only panitumumab neutralised both EGFRvIII and wtEGFR, resulting in superior anti-proliferative effects and nullification of downstream signalling. Tracking of fluorescent pani

Who reads Association of MTHFR gene polymorphisms with glioma and meningioma patients in Indian population?

Author

R. Kumawat; S.H. Gowda; E. Debnath; S. Rashid; R. Niwas; A. Suri; C. Sarkar; S. Sinha; K. Chosdol

Publisher

Oxford University Press; Elsevier BV (ISSN 0923-7534)

Published

2018

Language

EN

Field

Medicine (Health Sciences)