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Can Quantitative Measures of T790M Allelic Fraction Predict Survival Outcomes in Patients Receiving Osimertinib? Observations From an Early Access Programme by O.S.H. Chan; V.H.F. Lee; S.F. Nyaw; M.T.Y. Kam; K.W.C. Lee; K.C. Lam is a Medicine article available to read on EtoBox.

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## Aims: Multiple studies have shown conflicting results on the correlation between the egfr t790m quantitative level and survival outcomes in osimertinib-treated patients. we sought to validate such correlations using data from an osimertinib early access programme (eap) providing access for metastatic non-small cell lung cancer patients with limited treatment options. ## Patients and methods: This observational, multicentre, retrospective analysis included eap participants who received osimertinib until disease progression, intolerable toxicities or death. digital droplet polymerase chain reaction-based quantitative plasma genotyping was carried out upon disease progression and data were analysed to explore the relationships between t790m mutant allele fraction (maf), t790m copy number, maf ratio and post-osimertinib overall survival. real-world treatment outcomes and safety were also evaluated. ## Results: Data from 156 eap participants were analysed (median follow-up 37.7 months). the median age was 62 years, 62.2% were women, 79.5% were never-smokers, 60.9% had eastern cooperative oncology group performance status 0/1. in patients with available plasma data (n = 114), t790m ma

Who reads Can Quantitative Measures of T790M Allelic Fraction Predict Survival Outcomes in Patients Receiving Osimertinib? Observations From an Early Access Programme?

Author

O.S.H. Chan; V.H.F. Lee; S.F. Nyaw; M.T.Y. Kam; K.W.C. Lee; K.C. Lam

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)