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Single-dose Kinetics of the Neuroleptic Drug Perazine in Psychotic Patients by Ursula Breyer-Pfaff; K. Nill; H. W. Schied; H. J. Gaertner; H. Giedke is a Neuroscience article available to read on EtoBox.

What is Single-dose Kinetics of the Neuroleptic Drug Perazine in Psychotic Patients about?

Eight male and two female unmedicated psychotic patients received 100 mg perazine orally and seven blood samples were taken within 25 h. Plasma levels of perazine and its demethylated metabolite were analyzed by HPLC with electrochemical detection. They exhibited large interindividual variations, with maximal concentrations as well as AUC values of perazine differing more than 10-fold. From the decay of plasma levels during the last 12-18 h half-lives were estimated to be between 7.5 and 16 h; they did not correlate with AUC. There was a significant positive correlation between AUC and age. Desmethylperazine was consistently present at lower concentrations than the parent drug during the first 12 h.

Who reads Single-dose Kinetics of the Neuroleptic Drug Perazine in Psychotic Patients?

Author

Ursula Breyer-Pfaff; K. Nill; H. W. Schied; H. J. Gaertner; H. Giedke

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1988

Language

EN

Field

Neuroscience (Life Sciences)