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Expression of Carcinoembryonic Antigen and Related Genes in Lung and Gastrointestinal Cancers by Joohang Kim; Frederic J. Kaye; Jerry G. Henslee; John E. Shively; Jae-Gahb Park; Shinn-Liang Lai; R. Ilona Linnoila; James L. Mulshine; Adi F. Gazdar is a Medicine article available to read on EtoBox.
What is Expression of Carcinoembryonic Antigen and Related Genes in Lung and Gastrointestinal Cancers about?
## Abstract Carcinoembryonic antigen (CEA), a tumor marker for lung cancers of small cell (SCLC) and non‐small cell (NSCLC) types, belongs in a multigene family which includes non‐specific cross‐reacting antigen (NCA) and biliary glycoprotein 1 (BGP). We used specific cDNA probes and a CEA immunoassay to determine the pattern of expression in normal and malignant lung and gastrointestinal (GI) tissues. Normal lung contained high amounts of NCA and a low concentration of CEA. All 3 genes were expressed discordantly in lung tumors and cell lines. In contrast, all three genes were expressed in most GI tumor cell lines. In both king and colorectal cell lines expression of NCA RNA was relatively high, while BGP RNA was relatively low, and the median concentrations of CEA were greater than in corresponding non‐malignant tissues. While CEA protein concentrations in lung cell lines were similar to those present in GI cell lines, the ratio Of NCA:CEA RNA was significantly higher in lung cancer lines than in colorectal lines. Thus, NCA constitutes most of the “CEA‐like” immunoreactivity previously described in lung cancers. There was excellent concordance between expression of CEA RNA and CE
Who reads Expression of Carcinoembryonic Antigen and Related Genes in Lung and Gastrointestinal Cancers?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Joohang Kim; Frederic J. Kaye; Jerry G. Henslee; John E. Shively; Jae-Gahb Park; Shinn-Liang Lai; R. Ilona Linnoila; James L. Mulshine; Adi F. Gazdar
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1992
- Language
- EN
- Field
- Medicine (Health Sciences)