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Frequent Expression of the Tumor Antigen Cak1 in Squamous‐cell Carcinomas by Kai Chang; Ira Pastan; Mark C. Willngham is a Medicine article available to read on EtoBox.

What is Frequent Expression of the Tumor Antigen Cak1 in Squamous‐cell Carcinomas about?

K I is a murine monoclonal antibody (MAb) derived from a hybridoma generated by the fusion of splenocytes of BALB/c mice immunized with a human ovarian tumor cell line, OVCAR-3. This antibody reacts strongly with epithelial ovarian tumors and mesotheliomas. The antigen recognized by MAb K I, designated CAKI, has recently been characterized as a 40-kDa protein probably anchored to the cell surface by glycosyl-phosphatidylinositol. Using immunoperoxidase histochemical methods, we examined 37 squamous-cell carcinoma (SqCC) samples from cervix, lung, esophagus and other origins, and I 2 normal squamous epithelia of the cervix and esophagus for their reactivity with MAb KI. Of the SqCC specimens, 81% showed K I reactivity with variable intensity, but none of I 2 normal tissue samples of squamous epithelia did so. Two patterns of CAKl expression in tumor samples were found, Le., a heterogeneous pattern with strong intensity, and a homogeneous pattern with weak intensity. Three carcinomas in situ of the larynx, vulva and esophagus were moderately positive with K I , suggesting that CAKl antigen may occur in the early stage of carcinogenesis of SqCC. The expression of CAKl was also compare

Who reads Frequent Expression of the Tumor Antigen Cak1 in Squamous‐cell Carcinomas?

Author

Kai Chang; Ira Pastan; Mark C. Willngham

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1992

Language

EN

Field

Medicine (Health Sciences)