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Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells by Chih‐Yeu Fang; Chia‐Huei Lee; Chung‐Chun Wu; Yu‐Ting Chang; Shu‐Ling Yu; Sheng‐Ping Chou; Ping‐Ting Huang; Chi‐Long Chen; Jia‐Woei Hou; Yao Chang; Ching‐Hwa Tsai; Kenzo Takada; Jen‐Yang Chen is a Medicine article available to read on EtoBox.
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## Abstract Nasopharyngeal carcinoma (NPC) is an endemic malignancy prevalent in South East Asia. Epidemiological studies have associated this disease closely with Epstein‐Barr virus (EBV) infection. Previous studies also showed that EBV reactivation is implicated in the progression of NPC. Thus, we proposed that recurrent reactivations of EBV may be important for its pathogenic role. In this study, NPC cell lines latently infected with EBV, NA and HA, and the corresponding EBV‐negative NPC cell lines, NPC‐TW01 (TW01) and HONE‐1, were treated with 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA) and sodium __n__‐butyrate (SB) for lytic cycle induction. A single treatment with TPA/SB revealed that DNA double‐strand breaks and formation of micronuclei (a marker for genome instability) were associated with EBV reactivation in NA and HA cells. Examination of EBV early genes had identified several lytic proteins, particularly EBV DNase, as potent activators that induced DNA double‐strand breaks and contribute to genome instability. Recurrent reactivations of EBV in NA and HA cells resulted in a marked increase of genome instability. In addition, the degree of chromosomal aberrations, as s
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- Author
- Chih‐Yeu Fang; Chia‐Huei Lee; Chung‐Chun Wu; Yu‐Ting Chang; Shu‐Ling Yu; Sheng‐Ping Chou; Ping‐Ting Huang; Chi‐Long Chen; Jia‐Woei Hou; Yao Chang; Ching‐Hwa Tsai; Kenzo Takada; Jen‐Yang Chen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)