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In Vitro Assessment of Right Ventricular Outflow Tract Anatomy and Valve Orientation Effects on Bioprosthetic Pulmonary Valve Hemodynamics by Nicole K. Schiavone; Christopher J. Elkins; Doff B. McElhinney; John K. Eaton; Alison L. Marsden is a Medicine article available to read on EtoBox.

What is In Vitro Assessment of Right Ventricular Outflow Tract Anatomy and Valve Orientation Effects on Bioprosthetic Pulmonary Valve Hemodynamics about?

## Purpose: The congenital heart defect tetralogy of fallot (tof) affects 1 in 2500 newborns annually in the us and typically requires surgical repair of the right ventricular outflow tract (rvot) early in life, with variations in surgical technique leading to large disparities in rvot anatomy among patients. subsequently, often in adolescence or early adulthood, patients usually require surgical placement of a xenograft or allograft pulmonary valve prosthesis. valve longevity is highly variable for reasons that remain poorly understood. ## Methods: This work aims to assess the performance of bioprosthetic pulmonary valves in vitro using two 3d printed geometries: an idealized case based on healthy subjects aged 11 to 13 years and a diseased case with a 150% dilation in vessel diameter downstream of the valve. each geometry was studied with two valve orientations: one with a valve leaflet opening posterior, which is the native pulmonary valve position, and one with a valve leaflet opening anterior. ## Results: Full three-dimensional, three-component, phase-averaged velocity fields were obtained in the physiological models using 4d flow mri. flow features, particularly vortex format

Who reads In Vitro Assessment of Right Ventricular Outflow Tract Anatomy and Valve Orientation Effects on Bioprosthetic Pulmonary Valve Hemodynamics?

Author

Nicole K. Schiavone; Christopher J. Elkins; Doff B. McElhinney; John K. Eaton; Alison L. Marsden

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)