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Engineered Neural Tissue Made Using Hydrogels Derived from Decellularised Tissues for the Regeneration of Peripheral Nerves by Simon C. Kellaway; Victoria Roberton; Joshua N. Jones; Rabea Loczenski; James B. Phillips; Lisa J. White is a Engineering article available to read on EtoBox.

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Engineered neural tissue (EngNT) promotes in vivo axonal regeneration. Decellularised materials (dECM) are complex biologic scaffolds that can improve the cellular environment and also encourage positive tissue remodelling in vivo. We hypothesised that we could incorporate a hydrogel derived from a decellularised tissue (dECMh) into EngNT, thereby providing an alternative to the currently used purified collagen I hydrogel for the first time. Decellularisation was carried out on bone (B-ECM), liver (LIV-ECM), and small intestinal (SIS-ECM) tissues and the resultant dECM was biochemically and mechanically characterised. dECMh differed in mechanical and biochemical properties that likely had an effect on Schwann cell behaviour observed in metabolic activity and contraction profiles. Cellular alignment was observed in tethered moulds within the B-ECM and SIS-ECM derived hydrogels only. No difference was observed in dorsal root ganglia (DRG) neurite extension between the dECMh groups and collagen I groups when applied as a coverslip coating, however, when DRG were seeded atop EngNT constructs, only the B-ECM derived EngNT performed similarly to collagen I derived EngNT. B-ECM EngNT furt

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Author

Simon C. Kellaway; Victoria Roberton; Joshua N. Jones; Rabea Loczenski; James B. Phillips; Lisa J. White

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)