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In vivo andin vitro degradation of glycine/DL-lactic acid copolymers by J. M. Schakenraad; P. Nieuwenhuis; I. Molenaar; J. Helder; P. J. Dijkstra; J. Feijen is a Medicine article available to read on EtoBox.

What is In vivo andin vitro degradation of glycine/DL-lactic acid copolymers about?

A series of copolymers of glycine and DLlactic acid with various compositions was synthesized and their in nis'o and in vitro degradation behavior was studied. For the in vioo examination, discs of the copolymer films were subcutaneously implanted in rats. The in vitro studies were carried out in phosphate buffer at pH = 7.4 and 37°C. The decrease in molecular weight, the loss of weight, and the tissue reactions of the different copolymers were determined after 2, 5, and 10 weeks. Poly(DLlactic acid) was used as reference material. The in ziiuo and in ziitro degradation behavior of the polymers was comparable. The decrease of molecular weight of the copolymers and poly(D1-lactic acid) in time was similar. The weight loss for copolymers with a higher mole fraction of glycine units started earlier. The copolymer with the highest content of glycine units disappeared completely within 10 weeks both in ZI"I and in vitro. The poly(D1-lactic acid) implant lost only 25% weight over the same period. Tissue reactions against all materials started with an acute inflammatory reaction caused by the trauma of implantation, followed by wound-healing processes, ending in a very mild foreign body r

Who reads In vivo andin vitro degradation of glycine/DL-lactic acid copolymers?

Author

J. M. Schakenraad; P. Nieuwenhuis; I. Molenaar; J. Helder; P. J. Dijkstra; J. Feijen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1989

Language

EN

Field

Medicine (Health Sciences)