Can I read ortho,ortho′-Substituted KITPHOS Monophosphines: Highly Efficient Ligands for Palladium-Catalyzed CC and C N Bond Formation on EtoBox?

ortho,ortho′-Substituted KITPHOS Monophosphines: Highly Efficient Ligands for Palladium-Catalyzed CC and C N Bond Formation by Simon Doherty; Julian G. Knight; John P. McGrady; Alexandra M. Ferguson; Nicholas A. B. Ward; Ross W. Harrington; William Clegg is a Chemistry article available to read on EtoBox.

What is ortho,ortho′-Substituted KITPHOS Monophosphines: Highly Efficient Ligands for Palladium-Catalyzed CC and C N Bond Formation about?

## Abstract __ortho,ortho′‐__Substitution of the phosphinoalkyne‐derived aryl ring in KITPHOS (11‐dicyclohexylphosphino‐12‐phenyl‐9,10‐ethenoanthracene) monophosphines enhances the performance of this class of ligand in palladium‐catalyzed Suzuki–Miyaura cross‐couplings and Buchwald–Hartwig aminations, compared with their unsubstituted and mono‐substituted counterparts. An alternative complementary synthesis of KITPHOS monophosphines has been developed and two new members of this family, 2,6‐Me~2~‐KITPHOS [11‐dicyclohexylphosphino‐12‐(2,6‐dimethylphenyl)‐9,10‐ethenoanthracene] and 2,6‐(MeO)~2~‐KITPHOS [11‐dicyclohexylphosphino‐12‐(2,6‐dimethoxyphenyl)‐9,10‐ethenoanthracene], have been prepared; palladium complexes of both are highly efficient catalysts for CC and CN bond formation with a range of electron‐rich and electron‐poor aromatic chlorides as well as heteroaryl chlorides.

Who reads ortho,ortho′-Substituted KITPHOS Monophosphines: Highly Efficient Ligands for Palladium-Catalyzed CC and C N Bond Formation?

Author

Simon Doherty; Julian G. Knight; John P. McGrady; Alexandra M. Ferguson; Nicholas A. B. Ward; Ross W. Harrington; William Clegg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 1615-4150)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)