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Repurposing Blood Glucose Test Strips for Identification of the Antimicrobial Colistin by Carla Lopez; Magdalena R Raykova; Damion K Corrigan; Charles W Knapp; Andrew C Ward is a Engineering article available to read on EtoBox.

What is Repurposing Blood Glucose Test Strips for Identification of the Antimicrobial Colistin about?

The presence and fate of antimicrobial residues in the environment is a subject of growing concern. Previous researchers have demonstrated the persistence of residues in soil and water. Additionally, antimicrobial resistance is a growing concern, particularly to public health, animal health and economic development. In this study, a low cost, commercial blood glucose meter was explored as the basis for detecting antimicrobial residues in conjunction with a microorganism sensitive to this residue. A microbial bioassay was developed based on the metabolic response of Geobacillus stearothermophilus, a sensitive bacteria used in the determination of antimicrobial residues in food products, by measuring changes in glucose as a result of metabolic activity. After optimizing experimental conditions, this sensing strategy was tested using bacterial cultures in the presence of colistin, a last-resort antibiotic used for human and animal health. Growth of G. stearothermophilus was measurable as a change in glucose concentration after 2–4 h incubation at 60 °C, when LB media was supplemented with 100 mg/dL of glucose. The lowest measured colistin concentration that resulted in inhibition of g

Who reads Repurposing Blood Glucose Test Strips for Identification of the Antimicrobial Colistin?

Author

Carla Lopez; Magdalena R Raykova; Damion K Corrigan; Charles W Knapp; Andrew C Ward

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Engineering (Physical Sciences)