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Targeting N6-methyladenosine RNA modification combined with immune checkpoint Inhibitors: A new approach for cancer therapy 1 1 Background 2 2 Mechanisms underlying tumour immunity 2 3 Tumour immune checkpoint inhibitors and their clinical application 3 4 ICI resistance 4 5 Epigenetic modification of m6A 4 6 The involvement of m6A methylation in the responses of immune cells 5 6.1 T cells 5 6.2 Dendritic cells 5 6.3 Macrophages 6 6.4 Natural killer cells 6 7 Association between m6A methylation and tumour immune checkpoint therapy 6 7.1 Nervous system tumours 6 7.2 Respiratory system tumours 6 7.3 Urinary system tumours 6 7.3.1 Renal carcinoma 6 7.3.2 Bladder cancer 7 7.4 Digestive system tumours 7 7.4.1 Gastric cancer 7 7.4.2 Oesophageal cancer 7 7.4.3 Colorectal cancer 7 7.4.4 Liver cancer 7 7.4.5 Pancreatic cancer 7 7.5 Genital system tumours 8 7.5.1 Breast cancer 8 7.5.2 Ovarian cancer 8 7.5.3 Prostate cancer 8 7.6 Blood system cancer 8 7.6.1 Acute myelocytic leukaemia 8 7.7 Other cancers 8 7.7.1 Melanoma 8 7.7.2 Oral squamous cell carcinoma 8 7.7.3 Squamous cell carcinoma of the head and neck 9 8 Therapeutic strategies targeting m6A regulators 9 9 Conclusions 9 CRediT authorshi

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Language

UND

Category

nonfiction