Can I read Dynamic 3d-mr mammography: Is there a benefit of sophisticated evaluation of enhancement curves for clinical routine? on EtoBox?

Dynamic 3d-mr mammography: Is there a benefit of sophisticated evaluation of enhancement curves for clinical routine? by Markus Müller-Schimpfle; Katja Ohmenhäuser; Jürgen Sand; Peter Stoll; Claus D. Claussen is a Medicine article available to read on EtoBox.

What is Dynamic 3d-mr mammography: Is there a benefit of sophisticated evaluation of enhancement curves for clinical routine? about?

## Abstract The purpose of the study was to compare standard analysis with pharmacokinetic analysis of time‐intensity curves in dynamic three‐dimensional (3D) MR mammography (MRM) for their capability of differentiating benign from malignant disease. Dynamic MRM of the whole breast was performed at 1.0 T using an axial fast low‐angle shot (FLASH) 3D sequence. For the standard evaluation, the enhancement of the first minute (__E__~1~) and the slope of enhancement from minute 2 to 10 (SE~2–10~) were calculated. For pharmacokinetic analysis, the amplitude of enhancement (__A__), distribution time (__t__~21~), and elimination time (__t__~el~) were computed. Sixty‐two histologically verified lesions were evaluated. The standard evaluation methods yielded a highly significant difference between benign and malignant disease for __E__~1~ (__P__ = .0008) and SE~2–10~ (__P__ = .0001). The pharmacokinetic parameters gained similarly significant __P__ values (__A, P__ = .0014; __t__~21~, __P__ = .0024; __t__~el~, __P__ = .0001). Both standard and pharmacokinetic analysis concordantly discriminated between benign and malignant lesions in discriminant analysis. Compared with standard analysis, a

Who reads Dynamic 3d-mr mammography: Is there a benefit of sophisticated evaluation of enhancement curves for clinical routine??

Author

Markus Müller-Schimpfle; Katja Ohmenhäuser; Jürgen Sand; Peter Stoll; Claus D. Claussen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

1997

Language

EN

Field

Medicine (Health Sciences)