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Ixekizumab Improves Patient-Reported Outcomes in Non-Radiographic Axial Spondyloarthritis: Results from the Coast-X Trial by Atul Deodhar; Philip Mease; Proton Rahman; Victoria Navarro-Compán; Helena Marzo-Ortega; Theresa Hunter; David Sandoval; Andris Kronbergs; Luis Leon; Mingyang Shan; Ann Leung; Kurt De Vlam; Vibeke Strand is a Medicine article available to read on EtoBox.

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## Introduction Ixekizumab, an interleukin-17A antibody, has shown efficacy in non-radiographic axial spondyloarthritis (nr-axSpA). The objectives of this analysis were (a) to measure improvement in ixekizumab-treated patients in Assessment of Spondyloarthritis International Society (ASAS) response domains and other patient-reported outcomes (PROs) and (b) to determine how ASAS responses were associated with changes in patient global disease activity (PtGA), spinal pain, function, stiffness, fatigue, and spinal pain at night. ## Methods COAST-X was a phase 3, 52-week multicenter, randomized, controlled trial investigating the efficacy and safety of 80-mg ixekizumab every 2 weeks (Q2W) and every 4 weeks (Q4W) in patients with active nr-axSpA. Changes from baseline in PROs were analyzed via mixed-effects models for repeated measures. Association analyses for ASAS responses used analysis of covariance with Scheffé’s method. ## Results Patients treated with ixekizumab Q2W and Q4W reported significantly greater improvements in PtGA, spinal pain, function, and stiffness at week 1, when these measures were first assessed, compared with placebo (__p__ < 0.05). ASAS40 responders, in compari

Who reads Ixekizumab Improves Patient-Reported Outcomes in Non-Radiographic Axial Spondyloarthritis: Results from the Coast-X Trial?

Author

Atul Deodhar; Philip Mease; Proton Rahman; Victoria Navarro-Compán; Helena Marzo-Ortega; Theresa Hunter; David Sandoval; Andris Kronbergs; Luis Leon; Mingyang Shan; Ann Leung; Kurt De Vlam; Vibeke Strand

Publisher

Springer-Verlag; [London]: Springer Healthcare, 2014; Springer Science and Business Media LLC (ISSN 2198-6576)

Published

2020

Language

EN

Field

Medicine (Health Sciences)