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Comparing Survival Outcomes of Gross Total Resection and Subtotal Resection with Radiotherapy for Craniopharyngioma: a Meta-analysis by Guoqing Wang; Xiaoyang Zhang; Mengzhao Feng; Fuyou Guo is a Medicine article available to read on EtoBox.

What is Comparing Survival Outcomes of Gross Total Resection and Subtotal Resection with Radiotherapy for Craniopharyngioma: a Meta-analysis about?

Background: Recent studies suggest that subtotal resection (STR) followed by radiation therapy (RT) is an appealing alternative to gross total resection (GTR) for craniopharyngioma, but it remains controversial. We conducted a meta-analysis to determine whether GTR is superior to STR with RT for craniopharyngioma. Materials and methods: A systematic search was performed for articles published until October 2017 in the PubMed, Embase, and Cochrane Central databases. The endpoints of interest are overall survival and progression-free survival. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated using a fixed or randomeffects model. The data were analyzed using Review Manager 5.3 software.Results: A total of 744 patients (seven cohort studies) were enrolled for analyses. There were no significant differences between the GTR and STR with RT groups when the authors compared the pooled HRs at the end of the follow-up period. Overall survival (pooled HR 1⁄4 0.76, 95% CI: 0.46-1.25, P 1⁄4 0.28) and progression-free survival (pooled HR 1⁄4 1.52, 95% CI: 0.42-5.44, P 1⁄4 0.52) were similar between the two groups. Conclusions: The current meta-analysis

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Author

Guoqing Wang; Xiaoyang Zhang; Mengzhao Feng; Fuyou Guo

Published

2018

Language

EN

Field

Medicine (Health Sciences)