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Synthesis and reactivity of novel γ-phosphate modified ATP analogues by Sarah E. Lee; Lucy M. Elphick; Alexandra A. Anderson; Laurent Bonnac; Emma S. Child; David J. Mann; Véronique Gouverneur is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and reactivity of novel γ-phosphate modified ATP analogues about?
We hereby present a simple yet novel chemical synthesis of a family of gamma-modified ATPs bearing functional groups on the gamma-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27(kip1) is also presented.
Who reads Synthesis and reactivity of novel γ-phosphate modified ATP analogues?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sarah E. Lee; Lucy M. Elphick; Alexandra A. Anderson; Laurent Bonnac; Emma S. Child; David J. Mann; Véronique Gouverneur
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)