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Intraluminal suture occlusion and ligation of the distal branch of internal carotid artery: An improved rat model of focal cerebral ischemia-reperfusion by Xiaofan Chu; Chuanjie Qi; Liangyu Zou; Xuejun Fu is a Neuroscience article available to read on EtoBox.

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In order to evaluate a modified method of reversible middle cerebral artery occlusion (MCAo), 50 male Sprague-Dawley rats were subjected randomly to reperfusion series (n = 30) with 3 h of MCAo followed by 69 h of reperfusion and permanent series (n = 20) with 24 h of MCAo only. Based on Longa's method, experimental group with ligation of the distal branch of the internal carotid artery (ICA) around the intraluminal suture and control group without ligation were included. Behavioral functions were evaluated at 3 h after occlusion and during a 3-day period after MCAo in reperfusion series, or at 3 and 24 h after occlusion in permanent series. Infarct volume (IFV) was measured by the 2,3,5-triphenyl tetrazolium chloride (TTC) method at end time point in each series, and intraluminal thrombus formation in ICA of the reperfusion series was evaluated. In the experimental groups, a 100% incidence of infarction was shown in two series which was significantly higher than that in the control group (40% in reperfusion series and 50% in permanent series, p < 0.05). The total IFV and subcortical IFV in the experimental group was 174.9 ± 6.2 and 101.8 ± 2.6 mm 3 in reperfusion series and 321.8

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Author

Xiaofan Chu; Chuanjie Qi; Liangyu Zou; Xuejun Fu

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-0270)

Published

2008

Language

EN

Field

Neuroscience (Life Sciences)