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Cytotoxic Activity Of Eriocaulon Cinereum R.br To Mcf-7 And Vero Cell Line by NUGRAHA, ARDE TOGA; PURNAMA, ASGAR; KOMARIAH, SITI NURUL; ANSHORI T, HADY; HADY ANSHORI T, is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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Objective: The aim of the study was to determine the strength of the Eriocaulon cinereum R.Br plant against breast cancer cells (MCF7) and cytotoxicagainst Vero cells.Methods: E. cinereum R.Br was taken from the province of Bangka Belitung and then extracted in stages with n-hexane, ethyl acetate, and methanol.Then, the ethyl acetate extract was fractionated using the vacuum liquid chromatography method with dichloromethane and ethyl acetate solvents.Sample was tested for MCF-7 cells and Vero cells using the MTT method (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The dataobtained is analyzed by probit SPSS.Results: The results of this study showed that the best IC50 extract was ethyl acetate extract with an IC50 value of 450.31 μg/ml. Then, ethyl acetateextract produced dichloromethane fraction with IC50 value of 443.52 μg/ml and ethyl acetate with IC50 value of 214.75 μg/ml. Ethyl acetate fractionwas also tested against Vero cells to see cytotoxic against normal human cells with IC50 679.11 μg/ml

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Author

NUGRAHA, ARDE TOGA; PURNAMA, ASGAR; KOMARIAH, SITI NURUL; ANSHORI T, HADY; HADY ANSHORI T,

Publisher

Innovare Academic Sciences; International Journal of Applied Pharmaceutics; Sagar: Avijeet Jain; Innovare Academic Sciences Pvt Ltd (ISSN 0975-7058)

Published

2019

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)