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Impact of the ISCHEMIA randomized clinical trial on the management of patients with chronic coronary syndrome by M Spagnolo; C Laudani; G Occhipinti; F Agnello; M Legnazzi; L Scalia; M S Mauro; C Rochira; S Finocchiaro; A Greco; D Capodanno is a Medicine article available to read on EtoBox.
What is Impact of the ISCHEMIA randomized clinical trial on the management of patients with chronic coronary syndrome about?
Abstract Background In the ISCHEMIA trial, patients with chronic coronary syndromes (CCS) and moderate or severe ischemia had no significant difference in combined ischemic events with an initial invasive compared with a conservative strategy [1]. Coronary computed tomography angiography (CCTA) was part of the pre-randomization workup of ISCHEMIA and is gaining popularity over ischemia testing or initial invasive coronary angiography (ICA) as the initial diagnostic strategy for CCS [2]. Purpose To analyse whether the results of the ISCHEMIA trial had a sizeable impact on the diagnostic algorithm for CCS by analysing trends in referral to ICA and/or revascularization. Methods ICAs performed in CCS patients between November 2019 and February 2022 at a high-volume centre were analysed. Two groups were defined based on procedure date: i) pre-ISCHEMIA, including ICAs performed before March 2020 (date of trial publication); ii) post-ISCHEMIA, including ICAs performed ≥3 months (i.e., blanking period) after trial publication. The primary outcome was the incidence of referral to ICA by CCTA. Secondary objectives included referral to ICA or revascularization by ischemia testing, referral to
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- Author
- M Spagnolo; C Laudani; G Occhipinti; F Agnello; M Legnazzi; L Scalia; M S Mauro; C Rochira; S Finocchiaro; A Greco; D Capodanno
- Publisher
- Oxford University Press (OUP)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)