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Determination of Telmisartan in Human Plasma by Liquid Chromatography–tandem Mass Spectrometry by Pengfei Li; Yingwu Wang; Yan Wang; Yunbiao Tang; J. Paul Fawcett; Yimin Cui; Jingkai Gu is a Chemistry article available to read on EtoBox.
What is Determination of Telmisartan in Human Plasma by Liquid Chromatography–tandem Mass Spectrometry about?
A rapid, selective and sensitive method for the determination of the angiotensin II receptor antagonist, telmisartan, in human plasma has been developed. Telmisartan and the internal standard, diphenhydramine, were extracted from plasma using diethyl ether-dichloromethane (60:40, v/v), and separated on a Zorbax extend C 18 column using methanol-10 mM ammonium acetate (85:15, v/v) adjusted to pH 4.5 after mixing with formic acid as mobile phase. Detection was carried out by multiple reaction monitoring on a Q-trap TM LC-MS/MS system with an ESI interface. The assay was linear over the range 0.5-600.0 ng/ml with a limit of quantitation of 0.5 ng/ml and a limit of detection of 0.05 ng/ml. Intra-and inter-day precision were <6.7% and <8.1%, respectively, and the accuracy was in the range 88.9-111.0%. The assay was applied to a pharmacokinetic study of telmisartan given as a single oral dose (80 mg) to healthy volunteers.
Who reads Determination of Telmisartan in Human Plasma by Liquid Chromatography–tandem Mass Spectrometry?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Pengfei Li; Yingwu Wang; Yan Wang; Yunbiao Tang; J. Paul Fawcett; Yimin Cui; Jingkai Gu
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)