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Pulmonary Function in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation by Paul A. Hoffmeister; David K. Madtes; Barry E. Storer; Jean E. Sanders is a Medicine article available to read on EtoBox.

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## Abstract ## Background The purpose of this study was to determine the prevalence of pulmonary dysfunction in pediatric hematopoietic cell transplant (HCT) survivors and to identify associated risk factors. ## Procedure In a cross‐sectional study, patients surviving at least 5 years after pediatric HCT were requested to undergo pulmonary function testing (PFT). Risk factors for restrictive lung disease (RLD) and obstructive lung disease (OLD) were analyzed using multivariate analysis. ## Results Among 472 patients contacted, 260 (55%) participated and 215 were selected for analysis. These patients were transplanted at a median age of 8.3 (0.3–18.0) years; 175 for hematologic malignancies and 40 for non‐malignant diseases. The preparative regimens for 133 patients included fractionated TBI (FTBI), 29 single‐fraction TBI (SFTBI), and 53 non‐TBI regimens. PFT was performed at a median of 10 (5.0–27.5) years after HCT. Forty percent of patients had either RLD or OLD (28% RLD, 9% OLD, 3% mixed RLD/OLD) and at least 15% had an isolated low‐DLCO. Moderate‐to‐severe impairment was present in 45% of patients with RLD or OLD. In multivariate analysis, risk factors associated with RLD inclu

Who reads Pulmonary Function in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation?

Author

Paul A. Hoffmeister; David K. Madtes; Barry E. Storer; Jean E. Sanders

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2006

Language

EN

Field

Medicine (Health Sciences)