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Can I read Neuroplasticity in Mood Disorders on EtoBox?
Neuroplasticity in Mood Disorders by Wayne C. Drevets is a Neuroscience article available to read on EtoBox.
What is Neuroplasticity in Mood Disorders about?
Neuroimaging and neuropathological studies of major depressive disorder (MDD) and bipolar disorder (BD) have identified abnormalities of brain structure in areas of the prefrontal cortex, amygdala, striatum, hippocampus, parahippocampal gyrus, and raphe nucleus. These structural imaging abnormalities persist across illness episodes, and preliminary evidence suggests they may in some cases arise prior to the onset of depressive episodes in subjects at high familial risk for MDD. In other cases, the magnitude of abnormality is reportedly correlated with time spent depressed. Postmortem histopathological studies of these regions have shown abnormal reductions of synaptic markers and glial cells, and, in rare cases, reductions in neurons in MDD and BD. Many of the regions affected by these structural abnormalities show increased glucose metabolism during depressive episodes. Because the glucose metabolic signal is dominated by glutamatergic transmission, these data support other evidence that excitatory amino acid transmission is elevated in limbic-cortical-striatal-pallidal-thalamic circuits during depression. Some of the subject samples in which these metabolic abnormalities have bee
Who reads Neuroplasticity in Mood Disorders?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Wayne C. Drevets
- Publisher
- Informa UK Limited
- Published
- 2004
- Language
- EN
- Field
- Neuroscience (Life Sciences)