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Cystamine Inhibits Transglutaminase and Caspase-3 Cleavage in Glutamate-exposed Astroglial Cells by R. Ientile; A. Campisi; G. Raciti; D. Caccamo; M. Currò; G. Cannavò; G. Li Volti; S. Macaione; A. Vanella is a Neuroscience article available to read on EtoBox.
What is Cystamine Inhibits Transglutaminase and Caspase-3 Cleavage in Glutamate-exposed Astroglial Cells about?
## Abstract Although the precise role of transglutaminase in cell death is unknown, several findings demonstrate that tissue transglutaminase selectively accumulates in cells undergoing apoptosis both in vivo and in vitro. Calcium‐dependent transglutaminase reactions are also implicated in several neurodegenerative diseases, including alterations in the release of excitatory amino acids. One prevalent theme in cell damage induced by excitotoxic stimuli in different regions of the CNS is that apoptosis may be executed by intracellular caspase proteases. Furthermore, the presence of functional ion channel‐gated receptors in glial cells suggests that also astrocytes can be susceptible to glutamate's toxic effects. In this study, we demonstrated that prolonged exposure to glutamate (100 μM) of cultured astrocytes caused an increase in the expression of tissue transglutaminase (tTG). This effect was prevented by preincubation with GYKI 52466, an antagonist of AMPA/KA receptors. Glutamate exposure also promoted an increase in caspase‐3 compared with control cultures. Confocal laser microscopy analysis demonstrated the presence of activated caspase‐3 in the cytoplasm as well as in the nuc
Who reads Cystamine Inhibits Transglutaminase and Caspase-3 Cleavage in Glutamate-exposed Astroglial Cells?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- R. Ientile; A. Campisi; G. Raciti; D. Caccamo; M. Currò; G. Cannavò; G. Li Volti; S. Macaione; A. Vanella
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)