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Age‐related and Zonal Anatomical Changes of Apparent Diffusion Coefficient Values in Normal Human Prostatic Tissues by Tsutomu Tamada; Teruki Sone; Shinya Toshimitsu; Shigeki Imai; Yoshimasa Jo; Koji Yoshida; Akira Yamamoto; Takenori Yamashita; Naoto Egashira; Kiyohisa Nagai; Masao Fukunaga is a Medicine article available to read on EtoBox.

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## Abstract ## Purpose To identify age‐related changes and differences in the diffusion of water molecules within the prostate, through diffusion‐weighted imaging (DWI) of the prostate gland in healthy adult Japanese men. ## Materials and Methods A total of 114 healthy male volunteers (mean age, 55 years; range, 24–81 years) underwent DWI of the prostate with a single‐shot echo‐planar imaging (EPI) sequence using b‐factors of 0 and 1000 seconds/mm^2^. Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined. ## Results ADC values measured within both PZ and CG regions of the prostate showed a uniform distribution, and no significant differences were found between evaluated regions. However, mean ADC values were 1.64 ± 0.27 ×10^−3^ mm^2^/second for PZ and 1.26 ± 0.12 ×10^−3^ mm^2^/second for CG, representing a significant difference. In addition, significant positive correlations were identified between ADC values for both PZ and CG regions and subject age (r = 0.526, __P__ < 0.0001; r = 0.190, __P__ = 0.0431, respectively). ## Conclusion AD

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Author

Tsutomu Tamada; Teruki Sone; Shinya Toshimitsu; Shigeki Imai; Yoshimasa Jo; Koji Yoshida; Akira Yamamoto; Takenori Yamashita; Naoto Egashira; Kiyohisa Nagai; Masao Fukunaga

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2008

Language

EN

Field

Medicine (Health Sciences)