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Hepatitis B genotypes, precore and core promoter mutants circulating in Tunisia by O. Bahri; I. Cheikh; N. Hajji; A. Djebbi; N. Maamouri; A. Sadraoui; N. Ben Mami; H. Triki is a Medicine article available to read on EtoBox.

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Hepatitis B virus (HBV) is characterized by genetic heterogeneity, including genotypes and mutations. Eight genotypes (A-H) have been identified throughout the world with a characteristic geographical distribution. Previous studies also suggest that the viral genotypes may correlate with differences in clinical features of the infection. Two types of mutations were particularly described, precore and basal promoter mutations; they may play an important role in the clinical outcome of HBV infection. The aim of this study was to investigate the prevalence of HBV genotypes and HBV variants in Tunisia, and their eventual association with severity of liver disease. Using a molecular method, HBV genotypes, precore and basal core promoter mutations were determined in 56 asymptomatic carriers and in 82 patients with histologically verified chronic liver disease and hepatocellular carcinoma (HCC). Three genotypes (D, A, and E) were detected; the prevalence was 80%, 8%, and 9%, respectively. No significant difference was observed for genotype D with clinical status. HBV mutants were detected in 93% of cases, precore mutants were the most prevalent. Basal core promoter mutants were observed i

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Author

O. Bahri; I. Cheikh; N. Hajji; A. Djebbi; N. Maamouri; A. Sadraoui; N. Ben Mami; H. Triki

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2006

Language

EN

Field

Medicine (Health Sciences)