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Permanent prostate implant using high activity seeds and inverse planning with fast simulated annealing algorithm: A 12-year Canadian experience by André-Guy Martin; Jean Roy; Luc Beaulieu; Jean Pouliot; François Harel; Eric Vigneault is a Medicine article available to read on EtoBox.

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## Purpose: To report outcomes and toxicity of the first canadian permanent prostate implant program. ## Methods and materials: 396 consecutive patients (gleason < or =6, initial prostate specific antigen (psa) < or =10 and stage t1-t2a disease) were implanted between june 1994 and december 2001. the median follow-up is of 60 months (maximum, 136 months). all patients were planned with fast-simulated annealing inverse planning algorithm with high activity seeds ([gt] 0.76 u). acute and late toxicity is reported for the first 213 patients using a modified rtog toxicity scale. the kaplan-meier biochemical failure-free survival (bffs) is reported according to the astro and houston definitions. ## Results: The bffs at 60 months was of 88.5% (90.5%) according to the astro (houston) definition and, of 91.4% (94.6%) in the low risk group (initial psa < or =10 and gleason < or =6 and stage 10, a gleason score of 7-8, and stage t2b-t3. the mean d90 was of 151 +/- 36.1 gy. the mean v100 was of 85.4 +/- 8.5% with a mean v150 of 60.1 +/- 12.3%. overall, the implants were well tolerated. in the first 6 months, 31.5% of the patients were free of genitourinary symptoms (gus), 12.7% had grade 3 g

Who reads Permanent prostate implant using high activity seeds and inverse planning with fast simulated annealing algorithm: A 12-year Canadian experience?

Author

André-Guy Martin; Jean Roy; Luc Beaulieu; Jean Pouliot; François Harel; Eric Vigneault

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)