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Epstein-Barr virus-induced IgE production in limiting dilution cultures of normal human B cells by Leonard D. Stein; Marcia A. Chan; Toshifumi Hibi; Hans-Michael Dosch is a Immunology and Microbiology article available to read on EtoBox.

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## Epstein-Barr virus-induced IgE production in limiting dilution cultures of normal human B cells* The induction of in vitro IgE production in human B cells from normal, nonatopic donors has been difficult and somewhat controversial. We report that IgE production is consistently observed in limiting dilution cultures of in vitro Epstein-Barr virus (EBV)-infected normal human B lymphocytes. The frequency of IgE-committed, EBV-responsive cells ranged from 1/810 to 1/10000 B lymphocytes, and it was similar in peripheral (blood, tonsil) and central (bone marrow) tissue sites. Poisson distribution analysis of these limiting dilution cultures suggested that IgE-committed B cells comprise 0.1-1% of all EBV-responsive B lymphocytes.

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Author

Leonard D. Stein; Marcia A. Chan; Toshifumi Hibi; Hans-Michael Dosch

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1986

Language

EN

Field

Immunology and Microbiology (Life Sciences)