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Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors : A multiinstitutional retrospective analysis of 41 patients by Kazuhiko Ogawa; Takafumi Toita; Katsumasa Nakamura; Takashi Uno; Hiroshi Onishi; Jun Itami; Naoto Shikama; Naokatsu Saeki; Yoshihiko Yoshii; Sadayuki Murayama is a Medicine article available to read on EtoBox.
What is Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors : A multiinstitutional retrospective analysis of 41 patients about?
## Abstract ## BACKGROUND The relative roles of surgical resection, radiotherapy, and chemotherapy in the management of patients with intracranial nongerminomatous malignant germ cell tumors have been controversial. The authors retrospectively investigated the results of different treatment regimens in patients with these tumors. ## METHODS The records of 41 patients who were treated between 1981 and 2001 were reviewed. They were grouped into patients with a good prognosis (__n__ = 3), an intermediate prognosis (__n__ = 24), and a poor prognosis (__n__ = 14) based on the histology of their tumors. Fifteen patients (37%) underwent surgical resection and received radiotherapy, and 26 patients (63%) also received chemotherapy. The median follow‐up of 18 patients who remained alive was 61 months (range, 14–194 months). ## RESULTS The 5‐year actuarial overall survival rates for patients in the good prognosis, intermediate prognosis, and poor prognosis groups were 100%, 68%, and 8%, respectively. In the analysis, histology alone had a statistically significant impact on overall survival (__P__ < 0.0001). All 3 patients in the good prognosis group were treated successfully with surgical r
Who reads Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors : A multiinstitutional retrospective analysis of 41 patients?
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- Author
- Kazuhiko Ogawa; Takafumi Toita; Katsumasa Nakamura; Takashi Uno; Hiroshi Onishi; Jun Itami; Naoto Shikama; Naokatsu Saeki; Yoshihiko Yoshii; Sadayuki Murayama
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)