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Identification of novel splice variants of the human catalytic subunit cβ of cAMP‐dependent protein kinase by Sigurd Ørstavik; Nils Reinton; Eirik Frengen; Bjørn Tore Langeland; Tore Jahnsen; Bjørn S. Skålhegg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Identification of novel splice variants of the human catalytic subunit cβ of cAMP‐dependent protein kinase about?
Four different isoforms of the catalytic subunit of cAMP‐dependent protein kinase, termed __Cα__, __Cβ__, Cγ and PrKX have been identified. Here we demonstrate that the human __Cβ__ gene encodes six splice variants, designated __Cβ1, Cβ2, Cβ3, Cβ4, Cβ4ab__ and __Cβ4abc__. The __Cβ__ splice variants differ in their N‐terminal ends due to differential splicing of four different forms of exon 1 designated exon 1‐1, 1‐2, 1‐3, 1‐4 and three exons designated a, b and c. All these exons are located upstream of exon 2 in the __Cβ__ gene. The previously identified human __Cβ__ variant has been termed __Cβ1__, and is similar to the __Cβ__ isoform identified in the mouse, ox, pig and several other mammals. Human __Cβ2__, which is the homologue of bovine __Cβ2__, has no homologue in the mouse. Human __Cβ3__ and __Cβ4__ are homologous to the murine __Cβ3__ and __Cβ2__ splice variants, whereas human __Cβ4ab__ and __Cβ4abc__ represent novel isofoms previously not identified in any other species. At the mRNA level, the __Cβ__ splice variants reveal tissue specific expression. __Cβ1__ was most abundantly expressed in the brain, with low‐level expression in several other tissues. The __Cβ3__ and __C
Who reads Identification of novel splice variants of the human catalytic subunit cβ of cAMP‐dependent protein kinase?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sigurd Ørstavik; Nils Reinton; Eirik Frengen; Bjørn Tore Langeland; Tore Jahnsen; Bjørn S. Skålhegg
- Publisher
- John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)