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Hydrophilized Polycaprolactone Nanofiber Mesh-embedded Poly(glycolic-co-lactic Acid) Membrane for Effective Guided Bone Regeneration by Wan Jin Cho; Jun Ho Kim; Se Heang Oh; Hyun Hee Nam; Jin Man Kim; Jin Ho Lee is a Engineering article available to read on EtoBox.

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## Abstract A novel guided bone regeneration (GBR) membrane was fabricated by an immersion precipitation of poly (glycolic‐__co‐__lactic acid) (PLGA)/Pluronic F127 solution impregnated in an electrospun polycaprolactone (PCL)/Tween 80 nanofiber mesh. The prepared PCL/Tween 80 nanofiber mesh‐embedded PLGA/Pluronic F127 membrane (hydrophilized PCL/PLGA hybrid membrane) had nano‐size pores on the top side (which can prevent from fibrous connective tissue infiltration but allow permeation of oxygen and nutrients) and micro‐size pores on the bottom side (which can improve adhesiveness with bone). From the comparisons of mechanical properties (tensile and suture pullout strengths), model nutrient (FITC‐labeled bovine serum albumin) permeability, and bone regeneration behavior using a rat model (skull bone defect) of the hybrid membrane with those of PLGA/Pluronic F127 membrane (asymmetrically porous, hydrophilized PLGA membrane), PCL/Tween 80 nanofiber mesh (electrospun, hydrophilized PCL nanofiber mesh), and a commercialized GBR membrane, Bio‐Gide® (collagen type I/III membrane), it was observed that the PCL/PLGA hybrid membrane seems to be highly desirable as a GBR membrane for the sel

Who reads Hydrophilized Polycaprolactone Nanofiber Mesh-embedded Poly(glycolic-co-lactic Acid) Membrane for Effective Guided Bone Regeneration?

Author

Wan Jin Cho; Jun Ho Kim; Se Heang Oh; Hyun Hee Nam; Jin Man Kim; Jin Ho Lee

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2008

Language

EN

Field

Engineering (Physical Sciences)