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Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis by Nasser M Al-Daghri; Omar S Al-Attas; Khalid Al-Rubeaan; Mehad Mohieldin; Mohammad Al-Katari; Alan F Jones; Sudhesh Kumar is a Medicine article available to read on EtoBox.
What is Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis about?
## Background Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in pre-diabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis. ## Methods 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using standard laboratory procedures. ## Results Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects. ## Conclusion Leptin is assoc
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- Author
- Nasser M Al-Daghri; Omar S Al-Attas; Khalid Al-Rubeaan; Mehad Mohieldin; Mohammad Al-Katari; Alan F Jones; Sudhesh Kumar
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1475-2840)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)