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Prazosin for Treating Sleep Disturbances in Adults with Posttraumatic Stress Disorder: a Systematic Review and Meta-analysis of Randomized Controlled Trials by Davit Khachatryan; Dianne Groll; Linda Booij; Amir A. Sepehry; Christian G. Schütz is a Medicine article available to read on EtoBox.
What is Prazosin for Treating Sleep Disturbances in Adults with Posttraumatic Stress Disorder: a Systematic Review and Meta-analysis of Randomized Controlled Trials about?
## Objective: Posttraumatic stress disorder (ptsd) is a disorder with significant sleep morbidity and limited treatment options. prazosin may constitute a novel management approach and has been tested recently in a number of trials. we conducted a meta-analysis to examine the effectiveness of prazosin for nightmares and other sleep disturbances in adults with ptsd. ## Method: A systematic review of databases for randomized, double-blind, placebo-controlled trials of adults diagnosed with ptsd and reporting sleep disturbances that were treated with prazosin was conducted in january 2015. no limitations were placed on language or year of publication. ## Results: Six randomized controlled trials of prazosin for sleep disturbances in patients with ptsd were included (sample n=240). we found that prazosin was statistically significantly more effective than placebo in improving sleep quality [g=0.987, 95% confidence interval (ci): 0.324-1.651] and in reducing overall ptsd symptoms (g=0.699, 95% ci: 0.139-1.260) and sleep disturbances in particular (g=0.799, 95% ci: 0.391-1.234). ## Conclusions: Prazosin showed medium-to-large and statistically significant effects on ptsd symptoms in gene
Who reads Prazosin for Treating Sleep Disturbances in Adults with Posttraumatic Stress Disorder: a Systematic Review and Meta-analysis of Randomized Controlled Trials?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Davit Khachatryan; Dianne Groll; Linda Booij; Amir A. Sepehry; Christian G. Schütz
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)